Difference between revisions of "Dihydroxialumini sodium carbonate"
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'''Dihydroxialumini sodium carbonate''' ([[International Nonproprietary Name|INN]]) or '''dihydroxyaluminum sodium carbonate''' ([[United States Adopted Name|USAN]]) is a [[basic salt|basic]] [[carbonate]] of [[aluminium]] and [[sodium]], used as an [[antacid]]. It is prepared by the reaction of an [[aluminium]] [[salt]] with excess [[sodium carbonate]] in the presence of [[sodium hydroxide]] at pH 7.2–10.5.<ref>{{citation | inventor-last = Kaufman | inventor-first = Jeffrey L. | assignee = Nicholas Pty. Ltd. | title = Preparation of dihydroxyaluminium sodium carbonate | country-code = US | patent-number = 4438085 | issue-date = 1984-03-20}}.</ref> It also occurs naturally as the mineral [[dawsonite]].<ref>{{WebMineral-ref | name = Dawsonite | url = http://webmineral.com/data/Dawsonite.shtml | accessdate = 2009-12-06}}. {{MinDat-ref | name = Dawsonite | id = 1240 | accessdate = 2009-12-06}}.</ref> | '''Dihydroxialumini sodium carbonate''' ([[International Nonproprietary Name|INN]]) or '''dihydroxyaluminum sodium carbonate''' ([[United States Adopted Name|USAN]]) is a [[basic salt|basic]] [[carbonate]] of [[aluminium]] and [[sodium]], used as an [[antacid]]. It is prepared by the reaction of an [[aluminium]] [[salt]] with excess [[sodium carbonate]] in the presence of [[sodium hydroxide]] at pH 7.2–10.5.<ref>{{citation | inventor-last = Kaufman | inventor-first = Jeffrey L. | assignee = Nicholas Pty. Ltd. | title = Preparation of dihydroxyaluminium sodium carbonate | country-code = US | patent-number = 4438085 | issue-date = 1984-03-20}}.</ref> It also occurs naturally as the mineral [[dawsonite]].<ref>{{WebMineral-ref | name = Dawsonite | url = http://webmineral.com/data/Dawsonite.shtml | accessdate = 2009-12-06}}. {{MinDat-ref | name = Dawsonite | id = 1240 | accessdate = 2009-12-06}}.</ref> | ||
| − | The mineral form has six-coordinate aluminium (four hydroxide ions and two ''trans'' carbonate ions) and six-coordinate sodium (four carbonate ions and two ''trans'' hydroxide ions) | + | The unusual International Nonproprietary Name (INN) arises from an uncertainty in the structure of the commercial product. The mineral form has six-coordinate aluminium (four hydroxide ions and two ''trans'' carbonate ions) and six-coordinate sodium (four carbonate ions and two ''trans'' hydroxide ions, with distorted octahedral coordination compressed along a threefold axis):<ref>{{citation | last1 = Frueh | first1 = A. J. | last2 = Golightly | first2 = J. P. | year = 1967 | title = The crystal structure of dawsonite NaAl(CO<sub>3</sub>)(OH)<sub>2</sub> | journal = Canadian Mineralogist | volume = 9 | issue = 1 | pages = 51–56}}.</ref> hence it is best described as a basic carbonate of sodium and aluminium. The commercial product is amorphous, and has been described either as a carbonate of the dihydroxidoaluminium(1+) cation [Al(OH)<sub>2</sub>]<sup>+</sup> with sodium; or as a sodium salt of the carbonatodihydroxidoaluminate(1−) anion [Al(CO<sub>3</sub>)(OH)<sub>2</sub>]<sup>−</sup> with a bidentate carbonato [[ligand]] and four-coordinate aluminium. |
==References== | ==References== | ||
Revision as of 16:27, 6 December 2009
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Dihydroxialumini sodium carbonate (INN) or dihydroxyaluminum sodium carbonate (USAN) is a basic carbonate of aluminium and sodium, used as an antacid. It is prepared by the reaction of an aluminium salt with excess sodium carbonate in the presence of sodium hydroxide at pH 7.2–10.5.[1] It also occurs naturally as the mineral dawsonite.[2]
The unusual International Nonproprietary Name (INN) arises from an uncertainty in the structure of the commercial product. The mineral form has six-coordinate aluminium (four hydroxide ions and two trans carbonate ions) and six-coordinate sodium (four carbonate ions and two trans hydroxide ions, with distorted octahedral coordination compressed along a threefold axis):[3] hence it is best described as a basic carbonate of sodium and aluminium. The commercial product is amorphous, and has been described either as a carbonate of the dihydroxidoaluminium(1+) cation [Al(OH)2]+ with sodium; or as a sodium salt of the carbonatodihydroxidoaluminate(1−) anion [Al(CO3)(OH)2]− with a bidentate carbonato ligand and four-coordinate aluminium.
References
- ↑ Kaufman, Jeffrey L. (Nicholas Pty. Ltd.) Preparation of dihydroxyaluminium sodium carbonate. US Patent 4438085, issued 20 March 1984.
- ↑ Dawsonite, <http://webmineral.com/data/Dawsonite.shtml> (accessed 6 December 2009), WebMineral.com. Dawsonite, <http://www.mindat.org/show.php?id=1240> (accessed 6 December 2009), MinDat.org.
- ↑ Frueh, A. J.; Golightly, J. P. The crystal structure of dawsonite NaAl(CO3)(OH)2. Canadian Mineralogist 1967, 9 (1), 51–56.
Further reading
- Długaszek, Maria; Fiejka, Maria A.; Graczyk, Alfreda; Aleksandrowicz, Janina C.; Slowikowska, Maria Effects of various aluminium compounds given orally to mice on Al tissue distribution and tissue concentrations of essential elements. Pharmacol. Toxicol. 2000, 86 (3), 135–39. PMID 10752672. DOI: 10.1034/j.1600-0773.2000.pto860308.x.
External links
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See also the corresponding article on Wikipedia. |
- Dihydroxyaluminum sodium carbonate in the United States Pharmacopeia (28th ed.)
- IPCS Environmental Health Criteria 194: Aluminium
- NLM Hazardous Substances Data Bank entry for Aluminum compounds
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