Difference between revisions of "Dihydroxialumini sodium carbonate"

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{{Chembox
 
{{Chembox
 
| Name = Dihydroxyaluminium sodium carbonate (general)
 
| Name = Dihydroxyaluminium sodium carbonate (general)
 +
| IUPACName = aluminium sodium carbonate bis(hydroxide)
 +
| Section1 = {{Chembox Identifiers
 +
|  CASNo = 539-68-4
 +
|  ChemSpiderID = 11347551
 +
|  ATCCode_prefix = A02
 +
|  ATCCode_suffix = AB04
 +
|  InChI = 1/CH2O3.Al.Na.2H2O/c2-1(3)4;;;;/h(H2,2,3,4);;;2*1H2/q;+3;+1 ​;;/p-4/rCH2O3.AlH2O2.Na/c2-1(3)4;2-1-3;/h(H2,2,3,4);2-3H;/q;2*+1/​p-2
 +
|  InChIKey = SEIGJEJVIMIXIU-GRHVGONVAA
 +
|  StdInChI = 1S/CH2O3.Al.Na.2H2O/c2-1(3)4;;;;/h(H2,2,3,4);;;2*1H2/q;+3;+​1;;/p-4
 +
|  StdInChIKey = SEIGJEJVIMIXIU-UHFFFAOYSA-J
 +
  }}
 +
| Section2 = {{Chembox Properties
 +
|  Formula = NaAl(CO<sub>3</sub>)(OH)<sub>2</sub>
 +
|  MolarMass = 143.99 g/mol
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|  Appearance = white powder
 +
  }}
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| Section7 = {{Chembox Hazards
 +
|  EUIndex = not listed
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|  FlashPt = non-flammable
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  }}
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}}
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{{FixBunching|mid}}
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{{Chembox
 +
| Name = Dihydroxyaluminium sodium carbonate
 
| IUPACName = Dihydroxidoaluminium(1+) sodium carbonate
 
| IUPACName = Dihydroxidoaluminium(1+) sodium carbonate
 
| Section1 = {{Chembox Identifiers
 
| Section1 = {{Chembox Identifiers
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|  EC-number = 240-536-4
 
|  EC-number = 240-536-4
 
|  ChemSpiderID = 11347551
 
|  ChemSpiderID = 11347551
−
|  ATCcode_prefix = A02
 
−
|  ATCcode_suffix = AB04
 
 
|  InChI = 1/CH2O3.Al.Na.2H2O/c2-1(3)4;;;;/h(H2,2,3,4);;;2*1H2/q;+3;+1 ​;;/p-4/rCH2O3.AlH2O2.Na/c2-1(3)4;2-1-3;/h(H2,2,3,4);2-3H;/q;2*+1/​p-2
 
|  InChI = 1/CH2O3.Al.Na.2H2O/c2-1(3)4;;;;/h(H2,2,3,4);;;2*1H2/q;+3;+1 ​;;/p-4/rCH2O3.AlH2O2.Na/c2-1(3)4;2-1-3;/h(H2,2,3,4);2-3H;/q;2*+1/​p-2
 
|  InChIKey = SEIGJEJVIMIXIU-GRHVGONVAA
 
|  InChIKey = SEIGJEJVIMIXIU-GRHVGONVAA
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'''Dihydroxialumini sodium carbonate''' ([[International Nonproprietary Name|INN]]) or '''dihydroxyaluminum sodium carbonate''' ([[United States Adopted Name|USAN]]) is a [[basic salt|basic]] [[carbonate]] of [[aluminium]] and [[sodium]], used as an [[antacid]]. It is prepared by the reaction of an [[aluminium]] [[salt]] with excess [[sodium carbonate]] in the presence of [[sodium hydroxide]] at pH&nbsp;7.2–10.5.<ref>{{citation | inventor-last = Kaufman | inventor-first = Jeffrey L. | assignee = Nicholas Pty. Ltd. | title =  Preparation of dihydroxyaluminium sodium carbonate | country-code = US | patent-number = 4438085 | issue-date = 1984-03-20}}.</ref> It also occurs naturally as the mineral [[dawsonite]].<ref>{{WebMineral-ref | name = Dawsonite | url = http://webmineral.com/data/Dawsonite.shtml | accessdate = 2009-12-06}}. {{MinDat-ref | name = Dawsonite | id = 1240 | accessdate = 2009-12-06}}.</ref>
 
'''Dihydroxialumini sodium carbonate''' ([[International Nonproprietary Name|INN]]) or '''dihydroxyaluminum sodium carbonate''' ([[United States Adopted Name|USAN]]) is a [[basic salt|basic]] [[carbonate]] of [[aluminium]] and [[sodium]], used as an [[antacid]]. It is prepared by the reaction of an [[aluminium]] [[salt]] with excess [[sodium carbonate]] in the presence of [[sodium hydroxide]] at pH&nbsp;7.2–10.5.<ref>{{citation | inventor-last = Kaufman | inventor-first = Jeffrey L. | assignee = Nicholas Pty. Ltd. | title =  Preparation of dihydroxyaluminium sodium carbonate | country-code = US | patent-number = 4438085 | issue-date = 1984-03-20}}.</ref> It also occurs naturally as the mineral [[dawsonite]].<ref>{{WebMineral-ref | name = Dawsonite | url = http://webmineral.com/data/Dawsonite.shtml | accessdate = 2009-12-06}}. {{MinDat-ref | name = Dawsonite | id = 1240 | accessdate = 2009-12-06}}.</ref>
  
−
The mineral form has six-coordinate aluminium (four hydroxide ions and two ''trans'' carbonate ions) and six-coordinate sodium (four carbonate ions and two ''trans'' hydroxide ions).<ref>{{citation | last1 = Frueh | first1 = A. J. | last2 = Golightly | first2 = J. P. | year = 1967 | title = The crystal structure of dawsonite NaAl(CO<sub>3</sub>)(OH)<sub>2</sub> | journal = Canadian Mineralogist | volume = 9 | issue = 1 | pages = 51–56}}.</ref>
+
The unusual International Nonproprietary Name (INN) arises from an uncertainty in the structure of the commercial product. The mineral form has six-coordinate aluminium (four hydroxide ions and two ''trans'' carbonate ions) and six-coordinate sodium (four carbonate ions and two ''trans'' hydroxide ions, with distorted octahedral coordination compressed along a threefold axis):<ref>{{citation | last1 = Frueh | first1 = A. J. | last2 = Golightly | first2 = J. P. | year = 1967 | title = The crystal structure of dawsonite NaAl(CO<sub>3</sub>)(OH)<sub>2</sub> | journal = Canadian Mineralogist | volume = 9 | issue = 1 | pages = 51–56}}.</ref> hence it is best described as a basic carbonate of sodium and aluminium. The commercial product is amorphous, and has been described either as a carbonate of the dihydroxidoaluminium(1+) cation [Al(OH)<sub>2</sub>]<sup>+</sup> with sodium; or as a sodium salt of the carbonatodihydroxidoaluminate(1−) anion [Al(CO<sub>3</sub>)(OH)<sub>2</sub>]<sup>−</sup> with a bidentate carbonato [[ligand]] and four-coordinate aluminium.<ref name="USP">{{citation | title = United States Pharmacopeia – National Formulary | edition = 30th | year = 2007 | page = 1950}}.</ref>
 +
 
 +
Trade names for products containing dihydroxyalumini sodium carbonate include: Kompensan,<ref>{{citation | first = Bonnie L. | last = Carson | date = October 2000 | title = Aluminum Compounds: Review of Toxicological Literature | url = http://ntp.niehs.nih.gov/?objectid=F52FF452-F1F6-975E-72A2FAAFE6CBDC6F | publisher = National Toxicology Program, U.S. Department of Health & Human Services}}.</ref> Minicid.<ref>{{citation | last = Marcussen | first = J. M. | title = The effect of common antacids on intragastric pH. With special reference to dihydroxy aluminium sodium carbonate (Minicid) | journal = Acta Med. Scand. | year = 1962 | pages = 451–57 | pmid = 13932928}}.</ref>
  
 
==References==
 
==References==
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==External links==
 
==External links==
 
{{Wikipedia|Dihydroxialumini sodium carbonate}}
 
{{Wikipedia|Dihydroxialumini sodium carbonate}}
−
*[http://www.newdruginfo.com/pharmacopeia/usp28/v28230/usp28nf23s0_m26270.htm Dihydroxyaluminum sodium carbonate] in the ''[[United States Pharmacopeia]]'' (28th ed.)
 
 
*{{EHC|194|name=Aluminium}}
 
*{{EHC|194|name=Aluminium}}
 
*{{HSDB|name=Aluminum compounds}}
 
*{{HSDB|name=Aluminum compounds}}

Latest revision as of 17:55, 6 December 2009

Dihydroxyaluminium sodium carbonate (general)
IUPAC name aluminium sodium carbonate bis(hydroxide)
Identifiers
InChI InChI=1/CH2O3.Al.Na.2H2O/c2-1(3)4;;;;/h(H2,2,3,4);;;2*1H2/q;+3;+1 ​;;/p-4/rCH2O3.AlH2O2.Na/c2-1(3)4;2-1-3;/h(H2,2,3,4);2-3H;/q;2*+1/​p-2
InChIKey SEIGJEJVIMIXIU-GRHVGONVAA
Standard InChI InChI=1S/CH2O3.Al.Na.2H2O/c2-1(3)4;;;;/h(H2,2,3,4);;;2*1H2/q;+3;+​1;;/p-4
Standard InChIKey SEIGJEJVIMIXIU-UHFFFAOYSA-J
CAS number [539-68-4]
ATC code A02AB04
ChemSpider 11347551
Properties
Chemical formula NaAl(CO3)(OH)2
Molar mass 143.99 g/mol
Appearance white powder
Hazards
EU index number not listed
Flash point non-flammable
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Dihydroxyaluminium sodium carbonate
IUPAC name Dihydroxidoaluminium(1+) sodium carbonate
Identifiers
InChI InChI=1/CH2O3.Al.Na.2H2O/c2-1(3)4;;;;/h(H2,2,3,4);;;2*1H2/q;+3;+1 ​;;/p-4/rCH2O3.AlH2O2.Na/c2-1(3)4;2-1-3;/h(H2,2,3,4);2-3H;/q;2*+1/​p-2
InChIKey SEIGJEJVIMIXIU-GRHVGONVAA
Standard InChI InChI=1S/CH2O3.Al.Na.2H2O/c2-1(3)4;;;;/h(H2,2,3,4);;;2*1H2/q;+3;+​1;;/p-4
Standard InChIKey SEIGJEJVIMIXIU-UHFFFAOYSA-J
CAS number [16482-55-6]
EC number 240-536-4
ChemSpider 11347551
Properties
Chemical formula [Al(OH)2]Na(CO3)
Molar mass 143.99 g/mol
Hazards
EU index number not listed
Flash point non-flammable
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Sodium carbonatodihydroxidoaluminate(1−)
IUPAC name Sodium carbonatodihydroxidoaluminate(1−)
Identifiers
CAS number [12011-77-7]
EC number 234-567-2
Properties
Chemical formula Na[Al(CO3)(OH)2]
Molar mass 143.99 g/mol
Hazards
EU index number not listed
Flash point non-flammable
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)

Dihydroxialumini sodium carbonate (INN) or dihydroxyaluminum sodium carbonate (USAN) is a basic carbonate of aluminium and sodium, used as an antacid. It is prepared by the reaction of an aluminium salt with excess sodium carbonate in the presence of sodium hydroxide at pH 7.2–10.5.[1] It also occurs naturally as the mineral dawsonite.[2]

The unusual International Nonproprietary Name (INN) arises from an uncertainty in the structure of the commercial product. The mineral form has six-coordinate aluminium (four hydroxide ions and two trans carbonate ions) and six-coordinate sodium (four carbonate ions and two trans hydroxide ions, with distorted octahedral coordination compressed along a threefold axis):[3] hence it is best described as a basic carbonate of sodium and aluminium. The commercial product is amorphous, and has been described either as a carbonate of the dihydroxidoaluminium(1+) cation [Al(OH)2]+ with sodium; or as a sodium salt of the carbonatodihydroxidoaluminate(1−) anion [Al(CO3)(OH)2]− with a bidentate carbonato ligand and four-coordinate aluminium.[4]

Trade names for products containing dihydroxyalumini sodium carbonate include: Kompensan,[5] Minicid.[6]

References

  1. ↑ Kaufman, Jeffrey L. (Nicholas Pty. Ltd.) Preparation of dihydroxyaluminium sodium carbonate. US Patent 4438085, issued 20 March 1984.
  2. ↑ Dawsonite, <http://webmineral.com/data/Dawsonite.shtml> (accessed 6 December 2009), WebMineral.com. Dawsonite, <http://www.mindat.org/show.php?id=1240> (accessed 6 December 2009), MinDat.org.
  3. ↑ Frueh, A. J.; Golightly, J. P. The crystal structure of dawsonite NaAl(CO3)(OH)2. Canadian Mineralogist 1967, 9 (1), 51–56.
  4. ↑ United States Pharmacopeia – National Formulary, 30th ed., 2007; p 1950.
  5. ↑ Carson, Bonnie L. Aluminum Compounds: Review of Toxicological Literature; National Toxicology Program, U.S. Department of Health & Human Services, October 2000, <http://ntp.niehs.nih.gov/?objectid=F52FF452-F1F6-975E-72A2FAAFE6CBDC6F>.
  6. ↑ Marcussen, J. M. The effect of common antacids on intragastric pH. With special reference to dihydroxy aluminium sodium carbonate (Minicid). Acta Med. Scand. 1962, 451–57. PMID 13932928.

Further reading

External links

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