Difference between revisions of "Aluminium clofibrate"

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| Name = Aluminium clofibrate
 
| Name = Aluminium clofibrate
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|  ChemSpiderID = 11644433
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|  EC-number = 246-477-0
 
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Revision as of 06:26, 14 December 2009

Aluminium clofibrate
Other names Alfibrate
Identifiers
CAS number [24818-79-9]
EC number 246-477-0
ATC code C10AB03
ChemSpider 11644433
Properties
Chemical formula C20H21AlCl2O7
Molar mass 471.26 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)

Aluminium clofibrate or alfibrate is the basic salt of aluminium with clofibric acid. It is one of the fibrate class of lipid modifying agents,[1] that has been used for the treatment of hypercholesterolemia.

Aluminium clofibrate was introduced to counter the mild stomach upsets which are sometimes associated with fibrate treatment. It is hydrolysed in the stomach to aluminium salts (known antacids) and clofibric acid. However, clofibrate treatment for hypercholesterolemia is now regarded as obsolete due to the unacceptable side-effect profile, particularly the incidence of gallstones.[2]

References

  1. ATC/DDD Index; WHO Collaborating Centre for Drug Statistics Methodology, <http://www.whocc.no/atcddd/indexdatabase/>. (accessed 5 December 2009).
  2. A co-operative trial in the primary prevention of ischaemic heart disease using clofibrate. Br. Heart J. 1978, 40 (10), 1069–1118. DOI: 10.1136/hrt.40.10.1069.