Detection of protein biomarkers for medical applications
Proteins that are produced in increased amounts in disease states of can serve as biomarkers to detect specific diseases. Accurate measurement of panels of protein biomarkers in serum, saliva, or tissue has the potential for early detection of disease and for helping direct individualized therapy. While single biomarkers are already used for detection or monitoring of cancers and heart disease, more reliable prediction and widespread use will ultimately require devices that measure panels of biomarker proteins for each disease. For point-of-care use, optimal methodologies need to be accurate, sensitive, cheap, and easy to use to facilitate rapid diagnosis, minimize sample decomposition, and decrease patient anxiety. This symposium will feature invited and contributed papers and will focus on progress toward protein detection for medical applications. It will feature methods such as electrochemical and surface plasmon resonance arrays, fluorescent arrays, mass spectrometry, magnetic bead-based methods, microfluidics, and other emerging technologies for sensitive, multiplexed protein determinations in biomedical samples.
Sponsors
This session is sponsored by the ACS Analytical Division. Join the analytical division, and enjoy:
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Session organizer
James F. Rusling, Professor of Chemistry and Cell Biology, University of Connecticut. James Rusling obtained a B.Sc. in Chemistry from Drexel University, and a Ph. D. in Analytical Chemistry from Clarkson University (1979). He is Professor of Chemistry at University of Connecticut, Professor of Cell Biology at University of Connecticut Health Center and Adjunct Professor of Chemistry at National University of Ireland in Galway. Current research includes electrochemical and mass spectrometry arrays for toxicity prediction, protein biomarker measurements for early cancer detection, and fundamental bioelectrochemistry. In 2009, he was awarded the American Chemical Society Division of Analytical Chemistry Award in Electroanalytical Chemistry, and also received a Walton Research Fellowship from Science Foundation Ireland. He has nearly 300 research papers, several books, and is also a musician who plays button accordion, guitar and other instruments in traditional Irish and American folk styles.
Program
Thursday, June 3, 9:00 AM - 12:10 PM
- Detection of Protein Biomarkers for Medical Applications
- Kellas 103
Organizer/Presider: James Rusling
9:00 161 Cancer Biomarkers for the Realization of Personalized Medicine. Vyomesh Patel, National Institute of Craniofacial and Dental Research, NIH
9:30 162 The Path to Absolute Protein Quantification Using LC-MS. Ala F. Nassar1, Jim F. Rusling1, Dustin C. Yaworsky2 and David Heywood2, (1)University of Connecticut, (2)Waters Corporation
10:00 163 Ultrathroughput Mass Spectrometry for Quantifying Apical Plasma Membrane CFTR. Bekim Bajrami, Pamela Diego and Xudong Yao, University of Connecticut
10:30 164 New Proteomics Approaches for Identification, Quantitation and Validation of New Serum Biomarkers. Izabela Sokolowska1, Supriya Mathur1, Melissa Butkiewicz1, Rama Yakubu1, Jonathan Samson1, Christopher Talbot1, Mary Ann Gawinowicz2, Alisa G. Woods3 and Costel C. Darie1, (1)Clarkson University, (2)Columbia University, (3)Padure Biomedical Consulting
11:00 Intermission
11:20 165 New Proteomics Approaches for Identification of Serum Biomarkers. Izabela Sokolowska, Supriya Mathur and Costel Darie, Clarkson University
11:40 166 Biocomputing Coding Concept Approach Based on Parallel and Multiplexed Enzyme Logic Gates for Multi-Injury Diagnosis. Evgeny Katz1, Joseph Wang2, Jan Halámek1, Joshua R. Windmiller2, Jian Zhou1, Min-Chieh Chuang2, Padmanabhan Santhosh2, Guinevere Strack1, Mary A. Arugula1, Soujanya Chinnapareddy1 and Vera Bocharova1, (1)Clarkson University, (2)University of California
Thursday, June 3, 1:45 PM - 4:35 PM
- Detection of Protein Biomarkers for Medical Applications
- Kellas 103
Organizer/Presider: James Rusling
1:45 253 Second Harmonic Scattering: A Novel, Label-Free Technique for Biomarker Detection. Ravindra Pandey1, Avik Basu2, Abhijit Chakrabarti2, Puspendu K. Das1 and Challa V. Kumar3, (1)Indian Institute of Science, (2)Saha Institute of Nuclear Physics, (3)University of Connecticut
2:15 254 Stable Functionalized Silver Nanoparticles for Improved Cancer Biomarker Detection. Bjoern M. Reinhard, Boston University
2:45 255 Novel Strategies for Designing Paper Based Colorimetric Devices for Point-of-Care Diagnosis Using Metal Oxide Nanoparticles. Maryna Ornatska, Erica Sharpe, Daniel Andreescu and Silvana Andreescu, Clarkson University
3:15 256 Measurement of Four Cancer Biomarker Proteins in Oral Cancer Cell Cultures Using a Nanoparticle-Based Immunoelectrochemical Array. Ruchika Malhotra1, Vyomesh Patel4, J. Silvio Gutkind4 and James F. Rusling1,2,3, (1)University of Connecticut, (2)University of Connecticut, (3)University of Connecticut Health Center, (4)National Institutes of Health
3:35 257 Microfluidic Device for the Electrochemical Detection of Multiple Protein Cancer Biomarkers. Bhaskara V. Chikkaveeraiah, Vigneshwara Mani, Hongyun Liu and James F. Rusling, University of Connecticut
3:55 258 Ultrasensitive Detection of Protein Biomarkers in Serum Using Magnetically Coupled Labeling with Surface Plasmon Resonance. Vigneshwaran Mani1, Sadagopan Krishnan1, Challa V. Kumar1 and James F. Rusling1,2, (1)University of Connecticut, (2)University of Connecticut Health Center
4:15 259 Multidrug Resistance Assessment Using Biological Scanning Electrochemical Microscopy. Sabine Kuss, Isabelle Beaulieu, Mohamed A. Mezour, Renaud Cornut, Borhane Annabi and Janine Mauzeroll, Université du Québec à Montréal
